Some 27,751 flights are scheduled to depart from UK airports over the October half-term, 2% more than last year, according to aviation analysts Cirium.
Tomorrow (Friday) will be the busiest day, with 3,098 departures.
The number of seats available during half-term is up 9% compared to 2019, before the pandemic.
However, the number of flights is down 2% compared to 2019, when there were 28,351.
The most popular international destinations are Dublin, Amsterdam, Alicante, Malaga and Paris CDG.
EasyJet is projected to be the busiest airline during the holiday period, followed by British Airways, Ryanair and Jet2.
Heathrow will see the largest number of departures, followed by Gatwick, Manchester, Stansted, and Edinburgh.
