Loganair is to close its base at Southampton Airport at the end of October.
As a result, its Southampton–Manchester and Manchester–Exeter services will be axed, with the final flights scheduled for Thursday 20 August.
The regional carrier said the move will see aircraft and crew redeployed to other parts of its network.
It will continue to operate flights from Southampton on a reduced basis, but it will no longer base an aircraft there.
Loganair said the decision comes amid wider efforts to improve efficiency across its operations.
Passengers with affected bookings will be contacted directly and offered alternative flights or refunds.
A Loganair spokesperson said: “Following a review of our wider network and operational setup, we have taken the difficult decision to close our Southampton operating base at the end of October.
“Southampton–Manchester and Manchester–Exeter services will operate for the final time on Thursday 20 August. Customers affected by these changes will be contacted directly and will be offered alternative options where available, or a refund where no suitable alternative exists.
“This demand-led decision is part of a wider strategic update, which sees changes to operating bases and overall network delivery.
“These decisions reflect the same disciplined, decisive approach that has driven previous improvements in Loganair’s punctuality and resilience, protecting the long-term future of the airline, our people, and the lifeline connectivity we provide to communities across our network.”
